Maktab Sains Paduka Seri Begawan Sultan (MSPSBS), also known as Paduka Seri Begawan Sultan Science College, is a government secondary school and sixth form college in Bandar Seri Begawan, Brunei. Established in 1966 and formally opened in 1971, it is regarded as Brunei's top government-run secondary school, focusing on science and mathematics education and preparing students for GCE 'O' and 'A' Level examinations. The school is known for its rigorous academic standards and notable alumni including members of the Brunei royal family.