McCall McPherson uses GLP medications for chronic hypothyroidism patients with metabolic resistance. Years of untreated hypothyroidism causes insulin and leptin resistance that doesn't resolve by normalizing thyroid hormones alone. He started prescribing GLPs for weight loss but found patients stayed on them for broader metabolic gains, calling them potentially the most transformative medical advance of his lifetime.
So, this is my other passion project. I didn't think I'd ever be as passionate about anything outside of thyroid, but I am. I started using GLPs in my patients because they're metabolically resistant. Like, we lose our metabolism with years and years of hypothyroidism. We become insulin resistant, leptin resistant, metabolically dysfunctional. And that doesn't unravel immediately just when I fix your thyroid hormones, because you have to unwind those years, decades— Right. Of that dysfunction. So, I used GLPs initially for weight loss. And what I found was it's great. People start it for weight loss, they continue it for entirely different reasons. And I think this is the biggest thing that will happen in my lifetime in medicine, these medications, and it has nothing to do with weight loss.
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